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Dr. Byron Guffee DMD

Dental clinic
5.0 (25 reviews) Updated Apr 10, 2026
26 Holly Creek Dr, Anderson, SC 29621

About Dr. Byron Guffee DMD

Dental care in Anderson’s western stretches includes Dr. Byron Guffee DMD, a clinic handling routine cleanings, fillings, and more complex procedures like crowns or extractions. The practice operates out of a standalone building near the intersection of Holly Creek Drive and Highway 187, where residential quiet meets the convenience of main-road access. This part of Anderson leans toward suburban sprawl, with chain retailers and local businesses sharing the landscape—making it a practical stop for those balancing errands with appointments.

General dentistry forms the backbone of the services here, from preventive exams to addressing cavities or gum health. Patients seeking restorative work—bridges, dentures, or implant consultations—will find those options listed as well. The address, 26 Holly Creek Dr, Anderson, SC 29621, places it just minutes from the bustle of Clemson Boulevard but without the traffic congestion. For anyone coordinating visits around work or school schedules, the location’s proximity to major routes simplifies planning.

Direct contact remains straightforward: the office can be reached at (864) 226-1752 for questions about availability or treatment details. Dental clinics in this area often serve a mix of long-term locals and newer residents drawn to Anderson’s growth, and this one fits that pattern. While the focus stays on clinical care, the setting reflects the broader shift of professional services moving into what were once quieter corners of the county.

First-time visitors might want to check the map for directions, especially if approaching from Exit 14 off I-85. The surrounding area blends commercial strips with wooded lots, a contrast that’s become typical as Anderson expands. No frills, no grand claims—just a dental office where the emphasis stays on the work itself.

This listing was last updated on April 10, 2026

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Business Details

Accessibility
Wheelchair accessible entrance
Wheelchair accessible parking lot
Wheelchair accessible restroom
Offerings
Cosmetic dentistry
Amenities
Restroom
Planning
Appointments recommended
Payments
Credit cards
Debit cards
NFC mobile payments